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A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development.

Shp-1 and Shp-2 are cytoplasmic protein tyrosine phosphatases that contain two Src homology 2 (SH2) domains. A negative regulatory role of Shp-1 in hematopoiesis has been strongly implicated by the phenotype of motheaten mice with a mutation in the Shp-1 locus, which is characterized by leukocyte hy...

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Bibliografiske detaljer
Main Authors: Qu, C K, Shi, Z Q, Shen, R, Tsai, F Y, Orkin, S H, Feng, G S
Format: Artigo
Sprog:Inglês
Udgivet: 1997
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC232398/
https://ncbi.nlm.nih.gov/pubmed/9271425
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