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Interaction of the 18.5-kD isoform of myelin basic protein with Ca(2+)-calmodulin: Effects of deimination assessed by intrinsic Trp fluorescence spectroscopy, dynamic light scattering, and circular dichroism

The effects of deimination (conversion of arginyl to citrullinyl residues) of myelin basic protein (MBP) on its binding to calmodulin (CaM) have been examined. Four species of MBP were investigated: unmodified recombinant murine MBP (rmMBP-Cit(0)), an engineered protein with six quasi-citrullinyl (i...

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Detalhes bibliográficos
Main Authors: Libich, David S., Hill, Christopher M.D., Bates, Ian R., Hallett, F. Ross, Armstrong, Souzan, Siemiarczuk, Aleksander, Harauz, George
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley-Blackwell 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323942/
https://ncbi.nlm.nih.gov/pubmed/12824496
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