Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor

We studied the non-native aggregation of recombinant human granulocyte stimulating factor (rhGCSF) in solution conditions where native rhGCSF is both conformationally stable compared to its unfolded state and at concentrations well below its solubility limit. Aggregation of rhGCSF first involves the...

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Main Authors: Chi, Eva Y., Krishnan, Sampathkumar, Kendrick, Brent S., Chang, Byeong S., Carpenter, John F., Randolph, Theodore W.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2003
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323861/
https://ncbi.nlm.nih.gov/pubmed/12717013
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