Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor

We studied the non-native aggregation of recombinant human granulocyte stimulating factor (rhGCSF) in solution conditions where native rhGCSF is both conformationally stable compared to its unfolded state and at concentrations well below its solubility limit. Aggregation of rhGCSF first involves the...

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Xehetasun bibliografikoak
Egile Nagusiak: Chi, Eva Y., Krishnan, Sampathkumar, Kendrick, Brent S., Chang, Byeong S., Carpenter, John F., Randolph, Theodore W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2003
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323861/
https://ncbi.nlm.nih.gov/pubmed/12717013
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