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Determination of the cyclic depsipeptide FK228 in human and mouse plasma by liquid chromatography with mass-spectrometric detection
An analytical method was developed and validated for the quantitative determination of the cyclic depsipeptide FK228 (romidepsin, formerly FR901228; NSC 630176), a histone deacetylase inhibitor, in human and mouse plasma. Calibration curves were linear in the concentration range of 2 to 1000 ng/ml....
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2323676/ https://ncbi.nlm.nih.gov/pubmed/18342585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2008.02.015 |
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