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Downregulation of Histone H3 Lysine 9 Methyltransferase G9a Induces Centrosome Disruption and Chromosome Instability in Cancer Cells

BACKGROUND: Modifications of the histone amino-terminal tails affect access of regulatory factors and complexes to chromatin and thereby influence biological processes. Cancer cells are characterized by prominent epigenetic dysregulation, including histone modifications. However, the functional role...

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Autori principali: Kondo, Yutaka, Shen, Lanlan, Ahmed, Saira, Boumber, Yanis, Sekido, Yoshitaka, Haddad, Bassem R., Issa, Jean-Pierre J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323574/
https://ncbi.nlm.nih.gov/pubmed/18446223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002037
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