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Cryoelectron Microscopy Structure of the DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs) at Subnanometer Resolution Reveals α-Helices and Insight into DNA Binding
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) regulates the non-homologous end joining pathway for repair of double-stranded DNA breaks. Here we present a 7Å resolution structure of DNA-PKcs determined by cryoEM single particle reconstruction. This structure is composed of density ro...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2323513/ https://ncbi.nlm.nih.gov/pubmed/18334221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.12.014 |
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