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GSH-dependent regulation of Fas-mediated caspase-8 activation by acrolein.
Activation of the cysteine protease caspase-8 by the death receptor Fas (CD95/APO-1) in B lymphoblastoid SKW6.4 cells or Jurkat T cells is associated with GSH depletion. Conversely, GSH depletion by the aldehyde acrolein (3–30 μM) was associated with inhibition of Fas-induced caspase-8 activation, a...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2323510/ https://ncbi.nlm.nih.gov/pubmed/17222828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2006.12.040 |
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