Osteopenia in Sparc (osteonectin) deficient mice: characterization of phenotypic determinants of femoral strength and changes in gene expression

Sparc null mutants have been generated independently via targeted mutations in exons 4 and 6. Previous studies have identified low turnover osteopenia in the 129Sv/C57Bl/6 exon 4 knockout. Since both Sparc null mutations result in complete absence of Sparc protein, similar phenotypic outcomes are li...

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Bibliographic Details
Main Authors: Mansergh, Fiona C., Wells, Timothy, Elford, Carole, Evans, Sam L, Perry, Mark J, Evans, Martin J., Evans, Bronwen A J
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323447/
https://ncbi.nlm.nih.gov/pubmed/17878319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00151.2007
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