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Osteopenia in Sparc (osteonectin) deficient mice: characterization of phenotypic determinants of femoral strength and changes in gene expression
Sparc null mutants have been generated independently via targeted mutations in exons 4 and 6. Previous studies have identified low turnover osteopenia in the 129Sv/C57Bl/6 exon 4 knockout. Since both Sparc null mutations result in complete absence of Sparc protein, similar phenotypic outcomes are li...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2323447/ https://ncbi.nlm.nih.gov/pubmed/17878319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00151.2007 |
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