Non-cell autonomous impairment of oligodendrocyte differentiation precedes CNS degeneration in the Zitter rat: Implications of macrophage/microglial activation in the pathogenesis

BACKGROUND: The zitter (zi/zi) rat, a loss-of-function mutant of the glycosylated transmembrane protein attractin (atrn), exhibits widespread age-dependent spongiform degeneration, hypomyelination, and abnormal metabolism of reactive oxygen species (ROS) in the brain. To date, the mechanisms underly...

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Bibliographic Details
Main Authors: Sakakibara, Shin-ichi, Nakadate, Kazuhiko, Ookawara, Shigeo, Ueda, Shuichi
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323389/
https://ncbi.nlm.nih.gov/pubmed/18394170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-9-35
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