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E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas.

The E2A gene products, E12 and E47, are critical for proper early B-cell development and commitment to the B-cell lineage. Here we reveal a new role for E2A in T-lymphocyte development. Loss of E2A activity results in a partial block at the earliest stage of T-lineage development. This early T-cell...

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Udgivet i:Mol Cell Biol
Principais autores: Bain, G, Engel, I, Robanus Maandag, E C, te Riele, H P, Voland, J R, Sharp, L L, Chun, J, Huey, B, Pinkel, D, Murre, C
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232330/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9234734/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.8.4782
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