E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas.
The E2A gene products, E12 and E47, are critical for proper early B-cell development and commitment to the B-cell lineage. Here we reveal a new role for E2A in T-lymphocyte development. Loss of E2A activity results in a partial block at the earliest stage of T-lineage development. This early T-cell...
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| Vydáno v: | Mol Cell Biol |
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| Hlavní autoři: | , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Taylor & Francis
1997
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232330/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9234734/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.8.4782 |
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