E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas.

The E2A gene products, E12 and E47, are critical for proper early B-cell development and commitment to the B-cell lineage. Here we reveal a new role for E2A in T-lymphocyte development. Loss of E2A activity results in a partial block at the earliest stage of T-lineage development. This early T-cell...

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Detalhes bibliográficos
Main Authors: Bain, G, Engel, I, Robanus Maandag, E C, te Riele, H P, Voland, J R, Sharp, L L, Chun, J, Huey, B, Pinkel, D, Murre, C
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC232330/
https://ncbi.nlm.nih.gov/pubmed/9234734
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