E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas.
The E2A gene products, E12 and E47, are critical for proper early B-cell development and commitment to the B-cell lineage. Here we reveal a new role for E2A in T-lymphocyte development. Loss of E2A activity results in a partial block at the earliest stage of T-lineage development. This early T-cell...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Mol Cell Biol |
|---|---|
| Prif Awduron: | , , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Taylor & Francis
1997
|
| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232330/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9234734/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.8.4782 |
| Tagiau: |
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
|