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Vaccination and Timing Influence SIV Immune Escape Viral Dynamics In Vivo
CD8+ cytotoxic T lymphocytes (CTL) can be effective at controlling HIV-1 in humans and SIV in macaques, but their utility is partly offset by mutational escape. The kinetics of CTL escape and reversion of escape mutant viruses upon transmission to MHC-mismatched hosts can help us understand CTL-medi...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2323283/ https://ncbi.nlm.nih.gov/pubmed/18225952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.0040012 |
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