Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy

Tau pathology is a hallmark of many neurodegenerative diseases including Alzheimer disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17). Genetic tau mutations can cause FTDP-17, and mice overexpressing tau mutants such as P301L tau are used as AD models. Howev...

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Autors principals: Lim, Jormay, Balastik, Martin, Lee, Tae Ho, Nakamura, Kazuhiro, Liou, Yih-Cherng, Sun, Anyang, Finn, Greg, Pastorino, Lucia, Lee, Virginia M.-Y., Lu, Kun Ping
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2008
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323189/
https://ncbi.nlm.nih.gov/pubmed/18431510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34308
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