Intervening with Urinary Tract Infections Using Anti-Adhesives Based on the Crystal Structure of the FimH–Oligomannose-3 Complex

BACKGROUND: Escherichia coli strains adhere to the normally sterile human uroepithelium using type 1 pili, that are long, hairy surface organelles exposing a mannose-binding FimH adhesin at the tip. A small percentage of adhered bacteria can successfully invade bladder cells, presumably via pathways...

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Detalhes bibliográficos
Main Authors: Wellens, Adinda, Garofalo, Corinne, Nguyen, Hien, Van Gerven, Nani, Slättegård, Rikard, Hernalsteens, Jean-Pierre, Wyns, Lode, Oscarson, Stefan, De Greve, Henri, Hultgren, Scott, Bouckaert, Julie
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323111/
https://ncbi.nlm.nih.gov/pubmed/18446213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002040
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