Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2.

Lignende værker

• GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells.
  af: Vazquez de Aldana, C R, et al.
  Udgivet: (1995)
• Mutations in the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2 alpha) that overcome the inhibitory effect of eIF-2 alpha phosphorylation on translation initiation.
  af: Vazquez de Aldana, C R, et al.
  Udgivet: (1993)
• Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation
  af: Ishimura, Ryuta, et al.
  Udgivet: (2016)
• Association of GCN1–GCN20 regulatory complex with the N-terminus of eIF2α kinase GCN2 is required for GCN2 activation
  af: Garcia-Barrio, Minerva, et al.
  Udgivet: (2000)
• Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2 alpha kinase GCN2.
  af: Wek, R C, et al.
  Udgivet: (1992)