Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2.

In the yeast Saccharomyces cerevisiae, phosphorylation of translation initiation factor eIF2 by protein kinase GCN2 leads to increased translation of the transcriptional activator GCN4 in amino acid-starved cells. The GCN1 and GCN20 proteins are components of a protein complex required for the stimu...

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Publicado en:	Mol Cell Biol
Autores principales:	Marton, M J, Vazquez de Aldana, C R, Qiu, H, Chakraburtty, K, Hinnebusch, A G
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 1997
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232301/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9234705/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.8.4474
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