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In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in Xeroderma pigmentosum patients

Xeroderma pigmentosum (XP) patients fail to remove pyrimidine dimers caused by sunlight and, as a consequence, develop multiple cancers in areas exposed to light. The second most common sign, present in 20–30% of XP patients, is a set of neurological abnormalities caused by neuronal death in the cen...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Reardon, Joyce T., Bessho, Tadayoshi, Kung, Hsiang Chuan, Bolton, Philip H., Sancar, Aziz
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23224/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9256505/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.17.9463
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