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p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity.

The pRB-related proteins p107 and p130 are thought to suppress growth in part through their associations with two important cell cycle kinases, cyclin A-cdk2 and cyclin E-cdk2, and transcription factor E2F. Although each protein plays a critical role in cell proliferation, the functional consequence...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Woo, M S, Sánchez, I, Dynlacht, B D
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1997
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC232210/
https://ncbi.nlm.nih.gov/pubmed/9199292
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