p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity.
The pRB-related proteins p107 and p130 are thought to suppress growth in part through their associations with two important cell cycle kinases, cyclin A-cdk2 and cyclin E-cdk2, and transcription factor E2F. Although each protein plays a critical role in cell proliferation, the functional consequence...
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| Published in: | Mol Cell Biol |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Taylor & Francis
1997
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232210/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9199292/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.7.3566 |
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