Ectopic TAL-1/SCL expression in phenotypically normal or leukemic myeloid precursors: proliferative and antiapoptotic effects coupled with a differentiation blockade.

The TAL-1 gene specifies a basic helix-loop-helix domain (bHLH) transcription factor, which heterodimerizes with E2A gene family proteins. tal-1 protein is abnormally expressed in the majority of T-cell acute lymphoblastic leukemias (T-ALLs). tal-1 is expressed and plays a significant role in normal...

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Vydáno v:	Mol Cell Biol
Hlavní autoři:	Condorelli, G L, Tocci, A, Botta, R, Facchiano, F, Testa, U, Vitelli, L, Valtieri, M, Croce, C M, Peschle, C
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis 1997
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232147/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9111367/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.5.2954
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Ectopic TAL-1/SCL expression in phenotypically normal or leukemic myeloid precursors: proliferative and antiapoptotic effects coupled with a differentiation blockade.

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