Ectopic TAL-1/SCL expression in phenotypically normal or leukemic myeloid precursors: proliferative and antiapoptotic effects coupled with a differentiation blockade.

The TAL-1 gene specifies a basic helix-loop-helix domain (bHLH) transcription factor, which heterodimerizes with E2A gene family proteins. tal-1 protein is abnormally expressed in the majority of T-cell acute lymphoblastic leukemias (T-ALLs). tal-1 is expressed and plays a significant role in normal...

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Main Authors: Condorelli, G L, Tocci, A, Botta, R, Facchiano, F, Testa, U, Vitelli, L, Valtieri, M, Croce, C M, Peschle, C
格式: Artigo
語言:Inglês
出版: 1997
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC232147/
https://ncbi.nlm.nih.gov/pubmed/9111367
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