Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cip1) by STAT5.

Although thrombopoietin (TPO) is known to play a fundamental role in both megakaryopoiesis and thrombopoiesis, the molecular mechanism of TPO-induced megakaryocytic differentiation is not known. In a human megakaryoblastic leukemia cell line, CMK, that showed some degree of megakaryocytic differenti...

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Hauptverfasser: Matsumura, I, Ishikawa, J, Nakajima, K, Oritani, K, Tomiyama, Y, Miyagawa, J, Kato, T, Miyazaki, H, Matsuzawa, Y, Kanakura, Y
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1997
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC232145/
https://ncbi.nlm.nih.gov/pubmed/9111365
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