A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways.

The role of the Grb2-SOS complex in insulin signal transduction was investigated with a deletion mutant of mSOS1 that lacks the guanine nucleotide exchange domain of the wild-type protein. Cells over-expressing either wild-type (CHO-IR/SOS cells) or mutant (CHO-IR/delta SOS cells) mSOS1 were establi...

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Vydáno v:	Mol Cell Biol
Hlavní autoři:	Sakaue, M, Bowtell, D, Kasuga, M
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis 1995
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231974/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7799946/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.1.379
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