A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways.
The role of the Grb2-SOS complex in insulin signal transduction was investigated with a deletion mutant of mSOS1 that lacks the guanine nucleotide exchange domain of the wild-type protein. Cells over-expressing either wild-type (CHO-IR/SOS cells) or mutant (CHO-IR/delta SOS cells) mSOS1 were establi...
Sparad:
| I publikationen: | Mol Cell Biol |
|---|---|
| Huvudupphov: | , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
Taylor & Francis
1995
|
| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231974/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7799946/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.1.379 |
| Taggar: |
Inga taggar, Lägg till första taggen!
|