The PEST-like sequence of I kappa B alpha is responsible for inhibition of DNA binding but not for cytoplasmic retention of c-Rel or RelA homodimers.

In most cells, proteins belonging to the Rel/NF-kappa B family of transcription factors are held in inactive form in the cytoplasm by an inhibitor protein, I kappa B alpha. Stimulation of the cells leads to degradation of the inhibitor and transit of active DNA-binding Rel/NF-kappa B dimers to the n...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Ernst, M K, Dunn, L L, Rice, N R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231969/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7823953/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.2.872
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