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Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.

Activation of phosphatidylinositol 3-kinase (PI3K) and activation of the 70/85-kDa S6 protein kinases (alpha II and alpha I isoforms, referred to collectively as pp70S6k) have been independently linked to the regulation of cell proliferation. We demonstrate that these kinases lie on the same signall...

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Udgivet i:Mol Cell Biol
Principais autores: Monfar, M, Lemon, K P, Grammer, T C, Cheatham, L, Chung, J, Vlahos, C J, Blenis, J
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231963/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7528328/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.1.326
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