Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression.

The tumor suppressor gene product p53 can activate and repress transcription. Both transcriptional activation and repression are thought to involve the direct interaction of p53 with the basal transcriptional machinery. Previous work has demonstrated an in vitro interaction between p53 and the TATA-...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Horikoshi, N, Usheva, A, Chen, J, Levine, A J, Weinmann, R, Shenk, T
Format: Artigo
Langue:Inglês
Publié: 1995
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC231940/
https://ncbi.nlm.nih.gov/pubmed/7799929
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires