Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression.

The tumor suppressor gene product p53 can activate and repress transcription. Both transcriptional activation and repression are thought to involve the direct interaction of p53 with the basal transcriptional machinery. Previous work has demonstrated an in vitro interaction between p53 and the TATA-...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Horikoshi, N, Usheva, A, Chen, J, Levine, A J, Weinmann, R, Shenk, T
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 1995
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231940/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7799929/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.1.227
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