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Cytokine suppression of protease activation in wild-type p53-dependent and p53-independent apoptosis

M1 myeloid leukemic cells overexpressing wild-type p53 undergo apoptosis. This apoptosis can be suppressed by some cytokines, protease inhibitors, and antioxidants. We now show that induction of apoptosis by overexpressing wild-type p53 is associated with activation of interleukin-1β-converting enzy...

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Bibliographic Details
Main Authors: Lotem, Joseph, Sachs, Leo
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences of the USA 1997
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC23189/
https://ncbi.nlm.nih.gov/pubmed/9256485
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