E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts.
The E2a-Pbx1 oncoprotein contains the transactivation domain of E2a joined to the DNA-binding homeodomain (HD) of Pbx1. In mice, E2a-Pbx1 transforms T lymphoblasts and fibroblasts and blocks myeloblast differentiation. Pbx1 and E2a-Pbx1 bind DNA as heterodimers with other HD proteins whose expressio...
Saved in:
| Published in: | Mol Cell Biol |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Taylor & Francis
1997
|
| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231876/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9032278/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.3.1503 |
| Tags: |
No Tags, Be the first to tag this record!
|