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Costimulation by B7-1 and LFA-3 targets distinct nuclear factors that bind to the interleukin-2 promoter: B7-1 negatively regulates LFA-3-induced NF-AT DNA binding.
We have characterized the regulation of nuclear factors involved in transcriptional control of the interleukin-2 (IL-2) promoter-enhancer activity in Jurkat T cells stimulated with superantigen presented on HLA-DR transfectants combined with the ligands LFA-3 (CD58) and B7-1 (CD80). Gel shift analys...
Kaydedildi:
Asıl Yazarlar: | , , , , |
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Materyal Türü: | Artigo |
Dil: | Inglês |
Baskı/Yayın Bilgisi: |
1997
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Konular: | |
Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC231856/ https://ncbi.nlm.nih.gov/pubmed/9032258 |
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