The murine C'-terminally alternatively spliced form of p53 induces attenuated apoptosis in myeloid cells.

Eitemau Tebyg

• Augmented DNA-binding activity of p53 protein encoded by a carboxyl-terminal alternatively spliced mRNA is blocked by p53 protein encoded by the regularly spliced form.
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• Species- and tissue-specific expression of the C-terminal alternatively spliced form of the tumor suppressor p53.
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• Immunologically distinct p53 molecules generated by alternative splicing.
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• Involvement of wild-type p53 in pre-B-cell differentiation in vitro.
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• Developmental expression and phylogenetic conservation of alternatively spliced forms of the C-terminal Binding Protein corepressor.
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