A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

Phosphatidylinositol (PI) 3-kinase is a cytoplasmic signaling molecule that is recruited to activated growth factor receptors after growth factor stimulation of cells. Activation of PI 3-kinase results in increased intracellular levels of 3' phosphorylated inositol phospholipids and the induction of...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Klippel, A, Kavanaugh, W M, Pot, D, Williams, L T
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 1997
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231758/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8972214/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.1.338
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