Sheltering of gamma-globin expression from position effects requires both an upstream locus control region and a regulatory element 3' to the A gamma-globin gene.

Integration position-independent expression of human globin transgenes in transgenic mice requires the presence of regulatory elements from the beta-globin locus control region (LCR) in the transgene construct. However, several recent studies have suggested that, while clearly necessary, such elemen...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Stamatoyannopoulos, J A, Clegg, C H, Li, Q
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1997
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231748/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8972204/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.1.240
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