Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors.

Understanding how cyclin-cdk complexes recognize their substrates is a central problem in cell cycle biology. We identified an E2F1-derived eight-residue peptide which blocked the binding of cyclin A and E-cdk2 complexes to E2F1 and p21. Short peptides spanning similar sequences in p107, p130, and p...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Adams, P D, Sellers, W R, Sharma, S K, Wu, A D, Nalin, C M, Kaelin, W G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231664/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8943316/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.12.6623
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