Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2.

Eukaryotic translation initiation factor 2B (eIF2B) is a five-subunit complex that catalyzes guanine nucleotide exchange on eIF2. Phosphorylation of the alpha subunit of eIF2 [creating eIF2(alphaP]) converts eIF2 x GDP from a substrate to an inhibitor of eIF2B. We showed previously that the inhibito...

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Vydáno v:	Mol Cell Biol
Hlavní autoři:	Yang, W, Hinnebusch, A G
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis 1996
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231662/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8887689/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.11.6603
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