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Signal-induced degradation of I(kappa)B(alpha): association with NF-kappaB and the PEST sequence in I(kappa)B(alpha) are not required.

Signal-induced degradation of I(kappa)B(alpha) via the ubiquitin-proteasome pathway requires phosphorylation on residues serine 32 and serine 36 followed by ubiquitination on lysines 21 and 22. We investigated the role of other regions of I(kappa)B(alpha) which may be involved in its degradation. He...

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Pubblicato in:Mol Cell Biol
Autori principali: Van Antwerp, D J, Verma, I M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 1996
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231606/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8887633/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.11.6037
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