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Signal-induced degradation of I(kappa)B(alpha): association with NF-kappaB and the PEST sequence in I(kappa)B(alpha) are not required.

Signal-induced degradation of I(kappa)B(alpha) via the ubiquitin-proteasome pathway requires phosphorylation on residues serine 32 and serine 36 followed by ubiquitination on lysines 21 and 22. We investigated the role of other regions of I(kappa)B(alpha) which may be involved in its degradation. He...

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Udgivet i:Mol Cell Biol
Principais autores: Van Antwerp, D J, Verma, I M
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231606/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8887633/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.11.6037
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