Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity.

Upon binding of platelet-derived growth factor (PDGF), the PDGF beta receptor (PDGFR) undergoes autophosphorylation on distinct tyrosine residues and binds several SH2-domain-containing signal relay enzymes, including phosphatidylinositol 3-kinase (PI3K), phospholipase C gamma (PLC gamma), the GTPas...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Klinghoffer, R A, Duckworth, B, Valius, M, Cantley, L, Kazlauskas, A
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 1996
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231592/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8816504/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.10.5905
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