Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity.

Lignende værker

• An SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathway
  af: Moniakis, John, et al.
  Udgivet: (2001)
• GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit.
  af: Kazlauskas, A, et al.
  Udgivet: (1992)
• Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity.
  af: Yoakim, M, et al.
  Udgivet: (1994)
• The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp.
  af: Kazlauskas, A, et al.
  Udgivet: (1993)
• The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1.
  af: Valius, M, et al.
  Udgivet: (1995)