Synergistic interaction of the Neu proto-oncogene product and transforming growth factor alpha in the mammary epithelium of transgenic mice.

Transgenic mice expressing either the neu proto-oncogene or transforming growth factor (TGF-alpha) in the mammary epithelium develop spontaneous focal mammary tumors that occur after a long latency. Since the epidermal growth factor receptor (EGFR) and Neu are capable of forming heterodimers that ar...

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Autori principali: Muller, W J, Arteaga, C L, Muthuswamy, S K, Siegel, P M, Webster, M A, Cardiff, R D, Meise, K S, Li, F, Halter, S A, Coffey, R J
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1996
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC231573/
https://ncbi.nlm.nih.gov/pubmed/8816486
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