Attenuated sensitivity to neuroactive steroids in γ-aminobutyrate type A receptor delta subunit knockout mice

γ-Aminobutyric acid (GABA) type A receptors mediate fast inhibitory synaptic transmission and have been implicated in responses to sedative/hypnotic agents (including neuroactive steroids), anxiety, and learning and memory. Using gene targeting technology, we generated a strain of mice deficient in...

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Bibliographic Details
Main Authors: Mihalek, Robert M., Banerjee, Pradeep K., Korpi, Esa R., Quinlan, Joseph J., Firestone, Leonard L., Mi, Zhi-Ping, Lagenaur, Carl, Tretter, Verena, Sieghart, Werner, Anagnostaras, Stephan G., Sage, Jennifer R., Fanselow, Michael S., Guidotti, Alessandro, Spigelman, Igor, Li, Zhiwei, DeLorey, Timothy M., Olsen, Richard W., Homanics, Gregg E.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC23157/
https://ncbi.nlm.nih.gov/pubmed/10536021
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