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Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype.

The Stat (signal transducer and activator of transcription) factors transmit cytokine, growth factor, and hormone responses. Seven members of the Stat gene family are known. MGF-Stat5a has been discovered as a mediator of the prolactin response in mammary epithelial cells. Two closely related varian...

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Udgivet i:Mol Cell Biol
Principais autores: Moriggl, R, Gouilleux-Gruart, V, Jähne, R, Berchtold, S, Gartmann, C, Liu, X, Hennighausen, L, Sotiropoulos, A, Groner, B, Gouilleux, F
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231569/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8816482/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.10.5691
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