Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes.
The scid gene product has been identified as the 460-kDa catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs p460), a member of the phosphatidylinositol 3-kinase family. DNA-PK activity is undetectable in scid cells, but the molecular basis for this defect has not been identified. Here w...
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| Опубліковано в:: | Mol Cell Biol |
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| Автори: | , , , , |
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Taylor & Francis
1996
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| Предмети: | |
| Онлайн доступ: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231550/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8816463/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.10.5507 |
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