A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis.
Human wild-type (wt) p53 can induce apoptosis in transiently transfected H1299 cells maintained at 37 degrees C, whereas tumor-derived mutant forms of p53 (with the mutation Ala-143, His-175, or Trp-248) fail to do so. At 37 degrees C, p53 with a mutation to Ala at amino acid 143 (p53Ala143) was tra...
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| Publicado en: | Mol Cell Biol |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Taylor & Francis
1996
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231498/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8756655/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.9.4961 |
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