A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis.

Human wild-type (wt) p53 can induce apoptosis in transiently transfected H1299 cells maintained at 37 degrees C, whereas tumor-derived mutant forms of p53 (with the mutation Ala-143, His-175, or Trp-248) fail to do so. At 37 degrees C, p53 with a mutation to Ala at amino acid 143 (p53Ala143) was tra...

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Publicado en:	Mol Cell Biol
Principais autores:	Friedlander, P, Haupt, Y, Prives, C, Oren, M
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis 1996
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231498/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8756655/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.9.4961
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