The N-terminal pleckstrin, coiled-coil, and IQ domains of the exchange factor Ras-GRF act cooperatively to facilitate activation by calcium.

We have recently shown that the neuronal exchange factor p140 Ras-GRF becomes activated in vivo in response to elevated calcium levels [C. L. Farnsworth, N. W. Freshney, L. B. Rosen, A. Ghosh, M. E. Greenberg, and L. A. Feig, Nature (London) 376:524-527, 1995]. Activation is mediated by calcium-indu...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Buchsbaum, R, Telliez, J B, Goonesekera, S, Feig, L A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231491/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8756648/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.9.4888
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