Cyclin-binding motifs are essential for the function of p21CIP1.
The cyclin-dependent kinase (Cdk) inhibitor p21 is induced by the tumor suppressor p53 and is required for the G1-S block in cells with DNA damage. We report that there are two copies of a cyclin-binding motif in p21, Cy1 and Cy2, which interact with the cyclins independently of Cdk2. The cyclin-bin...
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| Pubblicato in: | Mol Cell Biol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Taylor & Francis
1996
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231467/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8756624/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.9.4673 |
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