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Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation.

Substantial evidence supports a critical role for the activation of the Raf-1/MEK/mitogen-activated protein kinase pathway in oncogenic Ras-mediated transformation. For example, dominant negative mutants of Raf-1, MEK, and mitogen-activated protein kinase all inhibit Ras transformation. Furthermore,...

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Udgivet i:Mol Cell Biol
Principais autores: Khosravi-Far, R, White, M A, Westwick, J K, Solski, P A, Chrzanowska-Wodnicka, M, Van Aelst, L, Wigler, M H, Der, C J
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231389/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8668210/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.7.3923
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