A dominant inhibitory mutant of the type II transforming growth factor beta receptor in the malignant progression of a cutaneous T-cell lymphoma.

In many cancers, inactivating mutations in both alleles of the transforming growth factor beta (TGF-beta) type 11 receptor (TbetaRII) gene occur and correlate with loss of sensitivity to TGF-beta. Here we describe a novel mechanism for loss of sensitivity to growth inhibition by TGF-beta in tumor de...

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Dettagli Bibliografici
Autori principali: Knaus, P I, Lindemann, D, DeCoteau, J F, Perlman, R, Yankelev, H, Hille, M, Kadin, M E, Lodish, H F
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1996
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC231343/
https://ncbi.nlm.nih.gov/pubmed/8668164
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